Journal: Diagnostics
Article Title: Evaluation of ViroTrack Sero Zika IgG/IgM, a New Rapid and Quantitative Zika Serological Diagnostic Assay
doi: 10.3390/diagnostics10060372
Figure Lengend Snippet: Serological study 3: Zika and dengue differential study. ( a ) ROC curve analysis by R for differentiation of ZIKV- from DENV-infected samples based on ZIKV IgG measurements: four groups of samples were analyzed, they are 25 pZIKV-infected samples, 25 DENVpZIKV-infected samples, 25 pDENV-infected samples and 25 sDENV samples; and ( b ) ROC curve analysis by R for differentiation of ZIKV- from DENV-infected samples based on ZIKV IgM measurements: four groups of samples were analyzed, they are 25 pZIKV-infected samples, 25 DENVpZIKV-infected samples, 25 pDENV-infected samples and 25 sDENV samples. ( c ) Violin plot of ViroTrack Sero Zika IgG/IgM measurements on ZIKV IgG and ( d ) IgM level from serum samples from four groups of samples as described in ( a ). ( e ) Violin plot of ViroTrack Sero Zika IgG/IgM measurements on ZIKV IgG level to compare primary and secondary DENV-infected samples from 25 serum samples with primary DENV infection collected at convalescent phase (around 20 days post-onset of illness), 25 serum samples with secondary infection collected at convalescent phase (around 20 days post-onset of illness), 20 serum samples with primary DENV infection (pDENV_>3MPO, sample collected 3 months post-onset of illness) and 20 serum samples with secondary DENV infection (sDENV_>3MPO, sample collected 3 months post-onset of illness). ( f ) Both sDENV samples from different stages of illness onset show significantly higher IgG levels than both groups of pDENV samples. ** p ≤ 0.05, **** p ≤ 0.0001.
Article Snippet: In serological study 1, we included three serial ZIKV samples (cat.no.1043-TDS-0220, 1043-TDS-0230 and 1043-TDS-0238) from the Dominican Republic (Boca Biolistics, Pompano Beach, FL, USA).
Techniques: Infection